The history of Corporate Social Responsibility (CSR) spans back to the 1950s. Once it headed its concentration on the responsibility of business leaders, practices started to take in various forms. The essence of the concept was revitalized in the next decades (Carroll, 1999). Concerns progressively developed into a crucial debate as today about who should be accounted for the sustainability of our economy, society and the environment. In the case of MENA region, the attention given to CSR is increasing due to rapid economic and population growth, environmental deprivation and not at least the influence from the private sector. Foreign investors also demand increased attempts for sustainability (The Arabia CSR Network, 2010). This article endeavours to define CSR and supply chain (SC) in order to provide understanding and their significance in demonstrating sincere commitment to sustainability with examples applied to the MENA region. Further, it will look at potential strategies towards a better integrated and sustainable supply chain and forward managerial requirements and challenges that can limit achievement of sustainable supply chain.